Richard Mannion

Richard Mannion is a consultant neurosurgeon at Addenbrooke’s Hospital in Cambridge. His main interests are spinal problems and brain tumours, including tumours of the skull base and pituitary gland. He works on all aspects of spinal disease interest him including infection, tumours, trauma and degenerative / wear and tear conditions. In particular, he is interested in the role of minimally invasive spinal surgery in treating people with spinal problems having witnessed the advantages of keyhole techniques in his own people. Richard completed a fellowship in Brisbane, Australia where he became skilled in all aspects minimally invasive spinal techniques and along with Mr. Trivedi, has built up a large minimally invasive spinal practice here in Cambridge.

Richard has a PhD in the field of chronic pain, having spent his research time in London and at Harvard University in Boston under Professor Clifford Woolf, a leading international pain specialist. Richard remains active in research and has published a large number of scientific papers on the subject of chronic pain, nerve pain, spinal disease and minimally invasive spinal techniques (see bibliography below).

Richard is married with 4 young children.

Key publications:

1.Woolf CJ, Mannion RJ, Neumann S (1998) Null mutations lacking substance: elucidating pain mechanisms by genetic pharmacology. Neuron 20(6):1063-6


2. Mannion RJ, Woolf CJ (1999) Neuropathic pain: the relationship between aetiology, symptoms, mechanisms and management. Lancet 353(9168):1959-1964


3. Mannion RJ, Costigan M, Ma QP, Decosterd I, Holstege JC, Ji RR, Lindsay RM, Acheson A, Wilkinson G, Woolf CJ (1999) Brain-Derived Neurotrophic Factor – a Centrally Acting Modulator of Stimulus-Induced Pain Hypersensitivity. Proceedings from the National Academy of Sciences 96:9385-9390


4. Doubell TP, Mannion RJ, Woolf CJ (1999) The dorsal horn – state dependent sensory processing. The Textbook of Pain. 4th Edition. Wall PD, Melzack R (Eds.). Churchill Livingstone, London


5. Mannion RJ, Costigan M, Woolf CJ (2000) Molecular approaches to the study of pain. Molecular Basis of pain Induction J.N. Wood (Ed.) Wiley-Liss New York

6. Mannion RJ, Woolf CJ (2000) A-fiber sprouting in the spinal cord after nerve injury – new pathways for pain? In: Nerve Regeneration. Ingoglia N & Murray M (Eds.) Marcel Dekker, Inc.

 7. Mannion RJ, Woolf CJ (2000) Pain Mechanisms and Management: A Central Perspective. Clinical Journal of Pain 16:S144-56


8. Mannion RJ, Woolf CJ (2002) Nociception and the Genesis of Persistent Pain. In: Diseases of the Nervous System: Clinical Neurobiology. 3rd Edition. Asbury, Goadsby, McCarthur, McDonald, McKhann (Eds.) Cambridge Press.


9. Mannion RJ, Cross J, Bradley, Coles JP, Chatfield D, Carpenter A, Pickard JD, Menon DK, Hutchinson PJA (2007) A mechanism-based MRI classification of traumatic brainstem injury and its relationship to outcome. Journal of Neurotrauma. 24(1):128-35.


10. Mannion RJ, Wilby M, Godward S, Lyratzopoulos G, Laing RJC (2007) The Surgical Management of Metastatic Spinal Disease – Prospective Assessment and Long Term Follow-Up. British Journal of Neurosurgery. 21(6):565-570


11. Scholz J, Mannion RJ, Hord DE, Griffin RS, Rawal B, Zheng H, Scoffings D, Phillips A, Guo J, Laing RJ, Abdi S, Decosterd I, Woolf CJ (2009) A novel tool for the assessment of pain: validation in low back pain. PLoS Med. 6(4):e1000047


12. Wood MJ, Mannion RJ (2010) Improving accuracy and reducing radiation exposure in minimally invasive spinal surgery – percutaneous lumbar pedicle screw placement using computer assisted navigation combined with continuous electromyographic monitoring. Journal of Neurosurgery. 12(5):533-9


13. Mannion RJ, Nowitzke AJ, Efendy, J Wood MJ (2010) Intradural extramedullary tumour removal using minimally invasive techniques – indications, advantages and difficulties. Neurosurgery. Dec 30. [Epub ahead of print]


14. Mannion RJ, Nowitzke AN, Wood MJ (2010) Promoting fusion in minimally invasive lumbar interbody stabilisation with low dose BMP-2 – but what is the cost? Spine J. Aug 24. [Epub ahead of print]



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